The overall objective of this project is to identify and/or confirm the presence of various potential health hazards in the general environment, with particular emphasis being given to possible carcinogens, mutagens, and teratogens. At the present time interest is being focused on the carcinogenic and/or reproductive-inhibiting potential of certain organic contaminants of finished drinking water. Comparisons of animal and human data with respect to the postnatal effects of prenatally administered DES are also being initiated.